Is X-linked Recessive Ichthyosis a High Risk for Basal Cell Carcinoma?

Diagnosis of recessive X-linked ichthyosis: quantitative HPLC/mass spectrometric analysis of plasma for cholesterol sulfate.

A specific, accurate liquid-chromatographic/mass-spectrometric (HPLC/MS) method for measurement of cholesterol sulfate in plasma from normal individuals and patients with recessive X-linked ichthyosis (RXLI) is described. The method is superior to previously described techniques because it measures the analyte intact rather than after hydrolysis. Traces of free cholesterol in the sample analyze...

OCT-4 Is a Good Predictive Biomarker for Local Recurrence in Head and Neck Basal Cell Carcinoma

Background and Aim: Basal cell carcinoma (BCC) is considered to be the most common malignancy in humans and occurs primarily in the skin especially in the head and neck region. Considering the high recurrence rate of the tumor, finding a marker for prediction of recurrence is very important. Cancer stem cells are a small subpopulation in the tumors that are related to tumorigenesis and recurren...

Basal cell carcinoma in a young woman: A case report

Basal cell carcinoma (BCC) is a malignant tumor of epithelial cells that is composed of cells similar to those in the basal area of the epidermis and its appendages. Ninety- five percent of individuals with BCC are between 40 and 79 years old. It rarely occurs in younger individuals. Herein, a 20- year- old woman with type III skin, who had a BCC on her chin is presented. Since the clinic...

Mechanisms in the association of cryptorchidism and X-linked recessive ichthyosis.

Steroid sulfatase of human leukocytes and epidermis and the diagnosis of recessive X-linked ichthyosis.

Patients with recessive X-linked ichthyosis, one of the inherited types of excessive stratum corneum cohesion, have deficient steroid sulfatase in fibroblasts grown from their dermis. Because of the expense and long period required to grow such cells, we have assayed this enzyme in peripheral blood leukocytes and found it to be undetectable in those from patients with this type of ichthyosis, b...